Mold Remediation >> Mold And Mildew

The so-called cellular slime mold and mildew, a unicellular organism that may transition into a multicellular organism under stress, has just been found to have a tissue structure that was previously thought to exist only in more sophisticated animals. What's more, Mold And Mildew two proteins that are needed by the slime mold and mildew to form this structure are similar to those that perform the same function in more sophistical animals.

Shortly after an animal embryo forms, it develops a single layer of cells that, shaped like a hollow ball, Mold And Mildew is empty at its center. Acting as a kind of "man behind the curtain" that directs these cells to organize into this hollow formation are several proteins that help each cell touch its neighbors but keep its top surface exposed to the formation's empty interior.

Even after animals grow beyond the embryo stage, the cells in many organs of their bodies maintain this type of hollow structure. These organs include those in the digestive tracts of animals, which feature a layer of cells, Mold And Mildew called epithelial cells, that face inward to form a hollow structure and are shaped asymmetrically to give organs their directionality. 

For example, the asymmetric epithelial cells of animal intestines face inward to form a hollow structure through which nutrients are absorbed. Likewise, the asymmetric epithelial cells of animal glands, such as salivary Mold And Mildew and endocrine glands, also face inward to form a hollow structure. But instead of absorbing substances as do the epithelial cells of animal intestines, these glandular epithelial cells secrete into their hollow structure substances that they produce.

With funding from the National Science Foundation, Daniel Dickinson, W. James Nelson and William Weis--all of Stanford University--took a careful look at the final, Mold And Mildew mature stage of slime mold and mildew development under a high-powered microscope. They report their results in the journal Science, March 11, 2011.

The slime mold and mildew spends most of its life as a single-celled organism, living in soil and preying on bacteria. However when food runs short, thousands of slime mold and mildew cells aggregate to form a mound. They then grow into a fruiting body--which is a stalk, a few millimeters tall, whose top peeks over the surface of the ground Mold And Mildew and holds spores. The researchers found that the organization and directionality of cells in this top part of the extending stalk are surprisingly similar to those of the epithelial cells of some organs of higher animals.

Dickinson and his colleagues also discovered that in order for the cells in the top of the slime mold and mildew's stalk to organize into an epithelium, Mold And Mildew they need analogues to two of the many proteins that are needed by animal cells to organize into an epithelium. Called alpha-catenin and beta-catenin, these slime mold and mildew analogues are genetically and biochemically similar to their animal versions. And when the researchers removed these analogues from the cells of slime mold and mildews, they lost their ability to organize correctly.

In addition to requiring proteins that are similar to those required by some animal epithelial tissues, Mold And Mildew the slime mold and mildew's epithelium tissue behaves similarly to the epithelial tissue of some animals--it is secretory. It secretes proteins that coat the stalk of the fruiting body and give it the rigidity it needs to send its spores out onto the ground in search of new food.

"We don't know whether the ancient ancestor of slime mold and mildews and animals was actually able to form an epithelium," says Dickinson, "but it must have had alpha-catenin Mold And Mildew and beta-catenin, and we suspect that these proteins had some role in organizing cells."

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